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Diagnostic Reagents

IMMUNOTICLES AUTO3 RPR

Features
Measurement Principle
Assessment of results
Measurement unit
Measured value

Features

High sensitivity measurement of nontreponemal antibody in serum and plasma
Enables rapid syphilis testing with plasma sample. Also suitable for non-office hour and emergency testing
Provides quantitative test results by automated testing for objective diagnosis
Mixing unnecessary - Set up reagents and use without mixing. (Mixing required for R2 when first opened)
Use on various automated analyzers

Measurement Principle

IMMUNOTICLES AUTO3 RPR is based on an optical absorbance method using Latex agglutination method.
Polystyrene-latex with nontreponemal antigen* on the surface and nontreponemal antibody in serum form agglutination clump by antigen-antibody reaction. Based on the principle that photometric change by this agglutination reaction relies on nontreponemal antibody value, this reagent measures nontreponemal antibody value in samples from the calibration curve drawn using RPR calibrator.

^*Cardiolipin, Lecithin, Cholesterol

Assessment of results

(1) Reference Cut-off Line

Results of 1.0U or more is assessed as positive.

(2) Precautions in Determination

Diagnosis of syphilis is ultimately made by a physician comprehensively combining results from IMMUNOTICLES AUTO3 RPR, clinical symptoms and other relevant tests. Positive measurement result of 1.0U or more with this reagent does not dismiss the possibility of false positive such as BFP(Biological False Positive). To confirm positive findings, reference examination by another method based on different principles such as FTA-ABS method should be performed.

Measurement unit

QC pooled serum with the result of 1 fold by RPR card test (quantitative test) corresponds to the measurement result of 1.0U with IMMUNOTICLES AUTO3 RPR.
When WHO International Standard is measured, the result holds a relation of 1.0U=1.0IU.